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Prof. Brent Wood

Affiliation : Director of Hematopathology, Childrens Hospital and Professor of Clinical Pathology at University of Southern California, LA, USA

Title of the Talk/Lab :Minimal Residual Disease (MRD) Monitoring in Acute Leukemia

Brent Wood obtained his MD and PhD from Loma Linda University followed by a residency in Anatomic and Clinical Pathology at the University of Washington in Seattle.  After a fellowship in Hematopathology at the University of Washington, Dr. Wood was on faculty for 30 years in the Department of Laboratory Medicine at the University of Washington where he was Professor and Director of the Hematopathology and Seattle Cancer Care Alliance Laboratories. Recently, he accepted a position as Director of Hematopathology at Childrens Hospital Los Angeles andis on the faculty at the University of Southern California where his responsibilities include clinical service work, translational research, and trainee education.  Flow cytometry and minimal residual disease detection are areas of particular interest.  He is responsible for implementing the first use of 10 color flow cytometry in the clinical laboratory and exploiting its potential for the identification of minimal residual disease in acute lymphoid leukemia and acute myeloid leukemia.  His laboratory serves as one of two national reference laboratories for the identification of minimal residual disease in childhood acute lymphoblastic leukemia for the Children’s Oncology Group,performs similar testing for the Southwest Oncology Group, and provides contract testing for a number of biotechnology and pharmaceutical companies.  Dr. Wood lectures both nationally and internationally on clinical applications of flow cytometry and is Past President of the International Clinical Cytometry Society.

Lecture: Minimal Residual Disease (MRD) Monitoring in Acute Leukemia

Relevant Literature:

  1. Wood, BL. 9 and 10 color flow cytometry in the clinical laboratory.  Archives of Path. and Lab. Med.  130: 680-690, 2006.
  2. Wood, BL. Myeloid neoplasms:  Myelodysplasia, myeloproliferative disorders, and acute myeloid leukemia.  Clinics in Lab Medicine 27: 551-575. 2007.
  3. Wood BL. Principles of Minimal Residual Disease Detection for Hematopoietic Neoplasms by Flow Cytometry. Cytometry Part B 2015. Cytometry B Clin Cytom. doi: 10.1002/cyto.b.21239. PMID: 25906832.
  4. Walter RB, Gooley TA, Wood BL, Milano F, Fang M, Sorror ML, Estey EH, Salter AI Lansverk E, Chien JW, Gopal AK, Appelbaum FR, and Pagel JM. (2011) Impact of Pre- Transplant Minimal Residual Disease, as Detected by Multiparametric Flow Cytometry, on Outcome of Myeloablative Hematopoietic Cell Transplantation for Acute Myeloid Leukemia. JCO 29:1190-7.
  5. Cherian S,Wood BL and Borowitz M. Flow Cytometry.  Clinical Diagnosis and Management by Laboratory Methods (Henry), W.B. Saunders, 2014.
  6. Wood BL (2020) Acute Myeloid Leukemia Minimal Residual Disease Detection: The Difference from Normal Approach. Curr Protoc Cytom 93(1):e73. doi: 10.1002/cpcy.73.

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